Make sure you state the question you would like to answer, then determine if an experiment or an observation is to be done, decide if the question needs one or two samples, if two samples are the samp...Make sure you state the question you would like to answer, then determine if an experiment or an observation is to be done, decide if the question needs one or two samples, if two samples are the samples matched, if this is a randomized experiment, if there is any blinding, and if this is a cross-sectional, retrospective, or prospective study.