The lecture notes are written from my perspective on what matters in a semester-long, first course in Biostatistics: concepts, context and practical advice along with a generous introduction to genera...The lecture notes are written from my perspective on what matters in a semester-long, first course in Biostatistics: concepts, context and practical advice along with a generous introduction to general linear models. The focus is on applied statistics with reference to other data science skill sets as needed. Concepts are illustrated by examples and multiple choice questions to “test” reader comprehension.